N-terminal pro-brain natriuretic peptide in the assessment of respiratory distress in term neonates
Nema prikaza
Autori
Markovic-Sovtić, GordanaKosutić, Jovan
Janković, Borisav
Bojanin, Dragana
Sovtić, Aleksandar
Radojičić, Zoran
Rakonjac, Zorica
Članak u časopisu (Objavljena verzija)
Metapodaci
Prikaz svih podataka o dokumentuApstrakt
Background N-terminal pro-brain natriuretic peptide (NT-proBNP) is used as a biomarker to differentiate congestive heart failure from lung disease in adults and children. The clinical significance of its use in term neonates has not yet been extensively studied. Methods NT-proBNP level was measured in 62 term neonates admitted for respiratory distress (RD): 38 with congenital heart disease (CHD) and 24 with pulmonary disease. The control group consisted of 28 healthy neonates. Findings of auscultation, chest radiography, Silverman-Anderson score and echocardiography were recorded for each patient. Blood samples for measuring NT-proBNP were collected on admission, when blood sampling was indicated for the clinical management of the newborn. Results In the control group NT-proBNP was significantly higher during the first week of life compared to the rest of the neonatal period (P LT 0.001). The RD group, regardless of etiology, had significantly higher NT-proBNP than the control group ...(P LT 0.001). Neonates with more severe RD had significantly higher NT-proBNP (P = 0.002). No significant difference was found between the RD group with CHD and those with pulmonary disease. Neonates with CHD and myocardial hypocontractility had significantly higher NT-proBNP than those with normal contractility (P = 0.022). Conclusion Term neonates with RD have significantly higher NT-proBNP than healthy neonates. A single measurement of NT-proBNP level cannot be used as the sole biomarker for distinguishing between cardiac and pulmonary cause of RD in term neonates.
Ključne reči:
term neonate / respiratory distress / pulmonary disease / N-terminal pro-brain natriuretic peptide / congenital heart diseaseIzvor:
Pediatrics International, 2014, 56, 3, 373-377Izdavač:
- Wiley, Hoboken
DOI: 10.1111/ped.12258
ISSN: 1328-8067
PubMed: 24274098
WoS: 000337521100020
Scopus: 2-s2.0-84901919953
Institucija/grupa
Fakultet organizacionih naukaTY - JOUR AU - Markovic-Sovtić, Gordana AU - Kosutić, Jovan AU - Janković, Borisav AU - Bojanin, Dragana AU - Sovtić, Aleksandar AU - Radojičić, Zoran AU - Rakonjac, Zorica PY - 2014 UR - https://rfos.fon.bg.ac.rs/handle/123456789/1237 AB - Background N-terminal pro-brain natriuretic peptide (NT-proBNP) is used as a biomarker to differentiate congestive heart failure from lung disease in adults and children. The clinical significance of its use in term neonates has not yet been extensively studied. Methods NT-proBNP level was measured in 62 term neonates admitted for respiratory distress (RD): 38 with congenital heart disease (CHD) and 24 with pulmonary disease. The control group consisted of 28 healthy neonates. Findings of auscultation, chest radiography, Silverman-Anderson score and echocardiography were recorded for each patient. Blood samples for measuring NT-proBNP were collected on admission, when blood sampling was indicated for the clinical management of the newborn. Results In the control group NT-proBNP was significantly higher during the first week of life compared to the rest of the neonatal period (P LT 0.001). The RD group, regardless of etiology, had significantly higher NT-proBNP than the control group (P LT 0.001). Neonates with more severe RD had significantly higher NT-proBNP (P = 0.002). No significant difference was found between the RD group with CHD and those with pulmonary disease. Neonates with CHD and myocardial hypocontractility had significantly higher NT-proBNP than those with normal contractility (P = 0.022). Conclusion Term neonates with RD have significantly higher NT-proBNP than healthy neonates. A single measurement of NT-proBNP level cannot be used as the sole biomarker for distinguishing between cardiac and pulmonary cause of RD in term neonates. PB - Wiley, Hoboken T2 - Pediatrics International T1 - N-terminal pro-brain natriuretic peptide in the assessment of respiratory distress in term neonates EP - 377 IS - 3 SP - 373 VL - 56 DO - 10.1111/ped.12258 UR - conv_1645 ER -
@article{ author = "Markovic-Sovtić, Gordana and Kosutić, Jovan and Janković, Borisav and Bojanin, Dragana and Sovtić, Aleksandar and Radojičić, Zoran and Rakonjac, Zorica", year = "2014", abstract = "Background N-terminal pro-brain natriuretic peptide (NT-proBNP) is used as a biomarker to differentiate congestive heart failure from lung disease in adults and children. The clinical significance of its use in term neonates has not yet been extensively studied. Methods NT-proBNP level was measured in 62 term neonates admitted for respiratory distress (RD): 38 with congenital heart disease (CHD) and 24 with pulmonary disease. The control group consisted of 28 healthy neonates. Findings of auscultation, chest radiography, Silverman-Anderson score and echocardiography were recorded for each patient. Blood samples for measuring NT-proBNP were collected on admission, when blood sampling was indicated for the clinical management of the newborn. Results In the control group NT-proBNP was significantly higher during the first week of life compared to the rest of the neonatal period (P LT 0.001). The RD group, regardless of etiology, had significantly higher NT-proBNP than the control group (P LT 0.001). Neonates with more severe RD had significantly higher NT-proBNP (P = 0.002). No significant difference was found between the RD group with CHD and those with pulmonary disease. Neonates with CHD and myocardial hypocontractility had significantly higher NT-proBNP than those with normal contractility (P = 0.022). Conclusion Term neonates with RD have significantly higher NT-proBNP than healthy neonates. A single measurement of NT-proBNP level cannot be used as the sole biomarker for distinguishing between cardiac and pulmonary cause of RD in term neonates.", publisher = "Wiley, Hoboken", journal = "Pediatrics International", title = "N-terminal pro-brain natriuretic peptide in the assessment of respiratory distress in term neonates", pages = "377-373", number = "3", volume = "56", doi = "10.1111/ped.12258", url = "conv_1645" }
Markovic-Sovtić, G., Kosutić, J., Janković, B., Bojanin, D., Sovtić, A., Radojičić, Z.,& Rakonjac, Z.. (2014). N-terminal pro-brain natriuretic peptide in the assessment of respiratory distress in term neonates. in Pediatrics International Wiley, Hoboken., 56(3), 373-377. https://doi.org/10.1111/ped.12258 conv_1645
Markovic-Sovtić G, Kosutić J, Janković B, Bojanin D, Sovtić A, Radojičić Z, Rakonjac Z. N-terminal pro-brain natriuretic peptide in the assessment of respiratory distress in term neonates. in Pediatrics International. 2014;56(3):373-377. doi:10.1111/ped.12258 conv_1645 .
Markovic-Sovtić, Gordana, Kosutić, Jovan, Janković, Borisav, Bojanin, Dragana, Sovtić, Aleksandar, Radojičić, Zoran, Rakonjac, Zorica, "N-terminal pro-brain natriuretic peptide in the assessment of respiratory distress in term neonates" in Pediatrics International, 56, no. 3 (2014):373-377, https://doi.org/10.1111/ped.12258 ., conv_1645 .