High Risk First Degree Relatives of Type 1 Diabetics: An Association with Increases in CXCR3(+) T Memory Cells Reflecting an Enhanced Activity of Th1 Autoimmune Response
2014
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Аутори
Miličić, TanjaJotić, Aleksandra
Marković, Ivanka
Lalić, Katarina
Jeremić, Veljko
Lukić, Ljiljana
Rajković, Nataša
Popadić, Dušan
Maćešić, Marija
Seferović, Jelena P.
Aleksić, Sandra
Stanarcić, Jelena
Civcić, Milorad
Lalić, Nebojša M.
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
We analyzed the level of (a)CXCR3(+) (Th1) and CCR4(+) (Th2) T memory cells (b) interferon-gamma. inducible chemokine (IP-10)( Th1) and thymus and activation-regulated chemokine ( TARC)( Th2), in 51 first degree relatives (FDRs) of type 1 diabetics (T1D) (17 high risk FDRs (GADA(+), IA-2(+)) and 34 low risk FDRs (GADA(-), IA- 2(-))), 24 recent-onset T1D (R-T1D), and 18 healthy subjects. T memory subsets were analyzed by using four-color immunofluorescence staining and flowcytometry. IP-10 and TARC were determined by ELISA. High risk FDRs showed higher levels of CXCR3(+) and lower level of CCR4(+) T memory cells compared to low risk FDRs (64.98 +/- 5.19 versus 42.13 +/- 11.11; 29.46 +/- 2.83 versus 41.90 +/- 8.58%, resp., P LT 0.001). Simultaneously, both IP-10 and TARC levels were increased in high risk versus low risk FDRs (160.12 +/- 73.40 versus 105.39 +/- 71.30; 438.83 +/- 120.62 versus 312.04 +/- 151.14 pg/ mL, P LT 0.05). Binary logistic regression analysis identified the lev...el of CXCR3(+) T memory cells as predictors for high risk FDRs, together with high levels of IP-10. The results imply that, in FDRs, the risk for T1D might be strongly influenced by enhanced activity of Th1 and diminished activity of Th2 autoimmune response.
Извор:
International Journal of Endocrinology, 2014, 2014Издавач:
- Hindawi Ltd, London
Финансирање / пројекти:
- Инсулинска резистенција: поређење улоге у настанку и развоју типа 2 дијабетеса, атеросклерозне васкуларне болести и неуродегенеративних обољења (RS-MESTD-Basic Research (BR or ON)-175097)
DOI: 10.1155/2014/589360
ISSN: 1687-8337
PubMed: 24778649
WoS: 000333837100001
Scopus: 2-s2.0-84899553489
Институција/група
Fakultet organizacionih naukaTY - JOUR AU - Miličić, Tanja AU - Jotić, Aleksandra AU - Marković, Ivanka AU - Lalić, Katarina AU - Jeremić, Veljko AU - Lukić, Ljiljana AU - Rajković, Nataša AU - Popadić, Dušan AU - Maćešić, Marija AU - Seferović, Jelena P. AU - Aleksić, Sandra AU - Stanarcić, Jelena AU - Civcić, Milorad AU - Lalić, Nebojša M. PY - 2014 UR - https://rfos.fon.bg.ac.rs/handle/123456789/1264 AB - We analyzed the level of (a)CXCR3(+) (Th1) and CCR4(+) (Th2) T memory cells (b) interferon-gamma. inducible chemokine (IP-10)( Th1) and thymus and activation-regulated chemokine ( TARC)( Th2), in 51 first degree relatives (FDRs) of type 1 diabetics (T1D) (17 high risk FDRs (GADA(+), IA-2(+)) and 34 low risk FDRs (GADA(-), IA- 2(-))), 24 recent-onset T1D (R-T1D), and 18 healthy subjects. T memory subsets were analyzed by using four-color immunofluorescence staining and flowcytometry. IP-10 and TARC were determined by ELISA. High risk FDRs showed higher levels of CXCR3(+) and lower level of CCR4(+) T memory cells compared to low risk FDRs (64.98 +/- 5.19 versus 42.13 +/- 11.11; 29.46 +/- 2.83 versus 41.90 +/- 8.58%, resp., P LT 0.001). Simultaneously, both IP-10 and TARC levels were increased in high risk versus low risk FDRs (160.12 +/- 73.40 versus 105.39 +/- 71.30; 438.83 +/- 120.62 versus 312.04 +/- 151.14 pg/ mL, P LT 0.05). Binary logistic regression analysis identified the level of CXCR3(+) T memory cells as predictors for high risk FDRs, together with high levels of IP-10. The results imply that, in FDRs, the risk for T1D might be strongly influenced by enhanced activity of Th1 and diminished activity of Th2 autoimmune response. PB - Hindawi Ltd, London T2 - International Journal of Endocrinology T1 - High Risk First Degree Relatives of Type 1 Diabetics: An Association with Increases in CXCR3(+) T Memory Cells Reflecting an Enhanced Activity of Th1 Autoimmune Response VL - 2014 DO - 10.1155/2014/589360 UR - conv_1631 ER -
@article{ author = "Miličić, Tanja and Jotić, Aleksandra and Marković, Ivanka and Lalić, Katarina and Jeremić, Veljko and Lukić, Ljiljana and Rajković, Nataša and Popadić, Dušan and Maćešić, Marija and Seferović, Jelena P. and Aleksić, Sandra and Stanarcić, Jelena and Civcić, Milorad and Lalić, Nebojša M.", year = "2014", abstract = "We analyzed the level of (a)CXCR3(+) (Th1) and CCR4(+) (Th2) T memory cells (b) interferon-gamma. inducible chemokine (IP-10)( Th1) and thymus and activation-regulated chemokine ( TARC)( Th2), in 51 first degree relatives (FDRs) of type 1 diabetics (T1D) (17 high risk FDRs (GADA(+), IA-2(+)) and 34 low risk FDRs (GADA(-), IA- 2(-))), 24 recent-onset T1D (R-T1D), and 18 healthy subjects. T memory subsets were analyzed by using four-color immunofluorescence staining and flowcytometry. IP-10 and TARC were determined by ELISA. High risk FDRs showed higher levels of CXCR3(+) and lower level of CCR4(+) T memory cells compared to low risk FDRs (64.98 +/- 5.19 versus 42.13 +/- 11.11; 29.46 +/- 2.83 versus 41.90 +/- 8.58%, resp., P LT 0.001). Simultaneously, both IP-10 and TARC levels were increased in high risk versus low risk FDRs (160.12 +/- 73.40 versus 105.39 +/- 71.30; 438.83 +/- 120.62 versus 312.04 +/- 151.14 pg/ mL, P LT 0.05). Binary logistic regression analysis identified the level of CXCR3(+) T memory cells as predictors for high risk FDRs, together with high levels of IP-10. The results imply that, in FDRs, the risk for T1D might be strongly influenced by enhanced activity of Th1 and diminished activity of Th2 autoimmune response.", publisher = "Hindawi Ltd, London", journal = "International Journal of Endocrinology", title = "High Risk First Degree Relatives of Type 1 Diabetics: An Association with Increases in CXCR3(+) T Memory Cells Reflecting an Enhanced Activity of Th1 Autoimmune Response", volume = "2014", doi = "10.1155/2014/589360", url = "conv_1631" }
Miličić, T., Jotić, A., Marković, I., Lalić, K., Jeremić, V., Lukić, L., Rajković, N., Popadić, D., Maćešić, M., Seferović, J. P., Aleksić, S., Stanarcić, J., Civcić, M.,& Lalić, N. M.. (2014). High Risk First Degree Relatives of Type 1 Diabetics: An Association with Increases in CXCR3(+) T Memory Cells Reflecting an Enhanced Activity of Th1 Autoimmune Response. in International Journal of Endocrinology Hindawi Ltd, London., 2014. https://doi.org/10.1155/2014/589360 conv_1631
Miličić T, Jotić A, Marković I, Lalić K, Jeremić V, Lukić L, Rajković N, Popadić D, Maćešić M, Seferović JP, Aleksić S, Stanarcić J, Civcić M, Lalić NM. High Risk First Degree Relatives of Type 1 Diabetics: An Association with Increases in CXCR3(+) T Memory Cells Reflecting an Enhanced Activity of Th1 Autoimmune Response. in International Journal of Endocrinology. 2014;2014. doi:10.1155/2014/589360 conv_1631 .
Miličić, Tanja, Jotić, Aleksandra, Marković, Ivanka, Lalić, Katarina, Jeremić, Veljko, Lukić, Ljiljana, Rajković, Nataša, Popadić, Dušan, Maćešić, Marija, Seferović, Jelena P., Aleksić, Sandra, Stanarcić, Jelena, Civcić, Milorad, Lalić, Nebojša M., "High Risk First Degree Relatives of Type 1 Diabetics: An Association with Increases in CXCR3(+) T Memory Cells Reflecting an Enhanced Activity of Th1 Autoimmune Response" in International Journal of Endocrinology, 2014 (2014), https://doi.org/10.1155/2014/589360 ., conv_1631 .