Prognostic value of cardiovascular calcifications in hemodialysis patients: a longitudinal study
Само за регистроване кориснике
2018
Аутори
Dimković, NadaSchlieper, Georg
Janković, Aleksandar
Đurić, Živka
Ketteler, Marcus
Damjanović, Tatjana
Đurić, Petar
Marinković, Jelena
Radojičić, Zoran
Marković, Nataša
Floege, Juergen
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
Cardiovascular calcifications (CVC) are present in up to 70% of non-diabetic dialysis patients. Sparse data are available on predictors of very long-term outcomes of such patients. The Belgrade Aachen Study on Calcification in Hemodialysis patients (BASCH study) aimed to study this using a comprehensive CVC assessment. We prospectively analyzed 220 hemodialysis patients followed for a mean of 76 months (median 73 months, range 6-160 months). We compared patients deceased from cardiovascular diseases (CVD) and survivors. Analyses included composite calcification scores (determined by combining ultrasound and X-ray analyses), demographic, clinical and laboratory data and pulse wave velocity (PWV). For survival analysis, patients were divided into group according to quartiles (Q). Compared to survivors, deceased patients from CVD were significantly older, more frequently hypertensive, had shorter dialysis times per week and lower Kt/V values, and they exhibited lower serum fetuin A, osteo...protegerin and hemoglobin as well as higher CRP levels. Composite calcification and Adragao scores were significantly higher in deceased patients from CVD as was PWV. Mean survival was 101 +/- 47 months (Q1), 87 +/- 51 month (Q2), 66 +/- 48 (Q3) and 54 +/- 45 months (Q4), p = 0.000. Cox multivariate regression analysis showed that independent predictors for cardiovascular mortality were composite calcification score in the range of third and fourth quartiles. Composite calcification score emerged as significant predictors of long-term survival in our group of largely non-diabetic dialysis patient population, finding that should be confirmed by intervention studies.
Кључне речи:
Long-term survival / Hemodialysis / Cardiovascular calcifications / Calcification promoters / Calcification inhibitorsИзвор:
International Urology and Nephrology, 2018, 50, 5, 939-946Издавач:
- Springer, Dordrecht
DOI: 10.1007/s11255-018-1821-1
ISSN: 0301-1623
PubMed: 29441480
WoS: 000431429000021
Scopus: 2-s2.0-85041914273
Институција/група
Fakultet organizacionih naukaTY - JOUR AU - Dimković, Nada AU - Schlieper, Georg AU - Janković, Aleksandar AU - Đurić, Živka AU - Ketteler, Marcus AU - Damjanović, Tatjana AU - Đurić, Petar AU - Marinković, Jelena AU - Radojičić, Zoran AU - Marković, Nataša AU - Floege, Juergen PY - 2018 UR - https://rfos.fon.bg.ac.rs/handle/123456789/1773 AB - Cardiovascular calcifications (CVC) are present in up to 70% of non-diabetic dialysis patients. Sparse data are available on predictors of very long-term outcomes of such patients. The Belgrade Aachen Study on Calcification in Hemodialysis patients (BASCH study) aimed to study this using a comprehensive CVC assessment. We prospectively analyzed 220 hemodialysis patients followed for a mean of 76 months (median 73 months, range 6-160 months). We compared patients deceased from cardiovascular diseases (CVD) and survivors. Analyses included composite calcification scores (determined by combining ultrasound and X-ray analyses), demographic, clinical and laboratory data and pulse wave velocity (PWV). For survival analysis, patients were divided into group according to quartiles (Q). Compared to survivors, deceased patients from CVD were significantly older, more frequently hypertensive, had shorter dialysis times per week and lower Kt/V values, and they exhibited lower serum fetuin A, osteoprotegerin and hemoglobin as well as higher CRP levels. Composite calcification and Adragao scores were significantly higher in deceased patients from CVD as was PWV. Mean survival was 101 +/- 47 months (Q1), 87 +/- 51 month (Q2), 66 +/- 48 (Q3) and 54 +/- 45 months (Q4), p = 0.000. Cox multivariate regression analysis showed that independent predictors for cardiovascular mortality were composite calcification score in the range of third and fourth quartiles. Composite calcification score emerged as significant predictors of long-term survival in our group of largely non-diabetic dialysis patient population, finding that should be confirmed by intervention studies. PB - Springer, Dordrecht T2 - International Urology and Nephrology T1 - Prognostic value of cardiovascular calcifications in hemodialysis patients: a longitudinal study EP - 946 IS - 5 SP - 939 VL - 50 DO - 10.1007/s11255-018-1821-1 UR - conv_2035 ER -
@article{ author = "Dimković, Nada and Schlieper, Georg and Janković, Aleksandar and Đurić, Živka and Ketteler, Marcus and Damjanović, Tatjana and Đurić, Petar and Marinković, Jelena and Radojičić, Zoran and Marković, Nataša and Floege, Juergen", year = "2018", abstract = "Cardiovascular calcifications (CVC) are present in up to 70% of non-diabetic dialysis patients. Sparse data are available on predictors of very long-term outcomes of such patients. The Belgrade Aachen Study on Calcification in Hemodialysis patients (BASCH study) aimed to study this using a comprehensive CVC assessment. We prospectively analyzed 220 hemodialysis patients followed for a mean of 76 months (median 73 months, range 6-160 months). We compared patients deceased from cardiovascular diseases (CVD) and survivors. Analyses included composite calcification scores (determined by combining ultrasound and X-ray analyses), demographic, clinical and laboratory data and pulse wave velocity (PWV). For survival analysis, patients were divided into group according to quartiles (Q). Compared to survivors, deceased patients from CVD were significantly older, more frequently hypertensive, had shorter dialysis times per week and lower Kt/V values, and they exhibited lower serum fetuin A, osteoprotegerin and hemoglobin as well as higher CRP levels. Composite calcification and Adragao scores were significantly higher in deceased patients from CVD as was PWV. Mean survival was 101 +/- 47 months (Q1), 87 +/- 51 month (Q2), 66 +/- 48 (Q3) and 54 +/- 45 months (Q4), p = 0.000. Cox multivariate regression analysis showed that independent predictors for cardiovascular mortality were composite calcification score in the range of third and fourth quartiles. Composite calcification score emerged as significant predictors of long-term survival in our group of largely non-diabetic dialysis patient population, finding that should be confirmed by intervention studies.", publisher = "Springer, Dordrecht", journal = "International Urology and Nephrology", title = "Prognostic value of cardiovascular calcifications in hemodialysis patients: a longitudinal study", pages = "946-939", number = "5", volume = "50", doi = "10.1007/s11255-018-1821-1", url = "conv_2035" }
Dimković, N., Schlieper, G., Janković, A., Đurić, Ž., Ketteler, M., Damjanović, T., Đurić, P., Marinković, J., Radojičić, Z., Marković, N.,& Floege, J.. (2018). Prognostic value of cardiovascular calcifications in hemodialysis patients: a longitudinal study. in International Urology and Nephrology Springer, Dordrecht., 50(5), 939-946. https://doi.org/10.1007/s11255-018-1821-1 conv_2035
Dimković N, Schlieper G, Janković A, Đurić Ž, Ketteler M, Damjanović T, Đurić P, Marinković J, Radojičić Z, Marković N, Floege J. Prognostic value of cardiovascular calcifications in hemodialysis patients: a longitudinal study. in International Urology and Nephrology. 2018;50(5):939-946. doi:10.1007/s11255-018-1821-1 conv_2035 .
Dimković, Nada, Schlieper, Georg, Janković, Aleksandar, Đurić, Živka, Ketteler, Marcus, Damjanović, Tatjana, Đurić, Petar, Marinković, Jelena, Radojičić, Zoran, Marković, Nataša, Floege, Juergen, "Prognostic value of cardiovascular calcifications in hemodialysis patients: a longitudinal study" in International Urology and Nephrology, 50, no. 5 (2018):939-946, https://doi.org/10.1007/s11255-018-1821-1 ., conv_2035 .