Androgen status in non-diabetic elderly men with heart failure
![](/themes/Miragerfos//images/openAccess.png)
2017
Аутори
Lončar, Goran![](/themes/Miragerfos/images/orcid.png)
Božić, Biljana
![](/themes/Miragerfos/images/orcid.png)
Nešković, Aleksandar N.
![](/themes/Miragerfos/images/orcid.png)
Cvetinović, Nataša
Lainscak, Mitja
Prodanović, Nenad
Dungen, H. D.
von Haehling, Stephan
Radojičić, Zoran
![](/themes/Miragerfos/images/orcid.png)
Trippel, Tobias
![](/themes/Miragerfos/images/orcid.png)
Putniković, Biljana
Marković-Nikolić, Nataša
Popović, Vera
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
Purpose: We aimed at evaluating androgen status (serum testosterone [TT] and estimated free testosterone [eFT]) and its determinants in non-diabetic elderly men with heart failure (HF). Additionally, we investigated its associations with body composition and long-term survival.Methods: Seventy three non-diabetic men with HF and 20 healthy men aged over 55years were studied. Echocardiography, 6-min walk test, grip strength, body composition measurement by DEXA method were performed. TT, sex hormone binding globulin, NT-proBNP, and adipokines (adiponectin and leptin) were measured. All-cause mortality was evaluated at six years of follow-up.Results: Androgen status (TT, eFT) was similar in elderly men with HF compared to healthy controls (4.791.65 vs. 4.45 +/- 1.68ng/ml and 0.409 +/- 0.277 vs. 0.350 +/- 0.204nmol/l, respectively). In HF patients, TT was positively associated with NT-proBNP (r=0.371, p=0.001) and adiponectin levels (r=0.349, p=0.002), while inverse association was noted w...ith fat mass (r=-0.413, p LT 0.001). TT and eFT were independently determined by age, total fat mass and adiponectin levels in elderly men with HF (p LT 0.05 for all). Androgen status was not predictor for all-cause mortality at six years of follow-up.Conclusions: In non-diabetic men with HF, androgen status is not altered and is not predictive of long-term outcome.
Кључне речи:
Testosterone / survival / men / heart failure / body composition / adipokinesИзвор:
Aging Male, 2017, 20, 4, 215-224Издавач:
- Taylor & Francis Ltd, Abingdon
Финансирање / пројекти:
- Неуроендокрина контрола секреције хормона раста код човека - нови изазови. Контрола енергетске хомеостазе код човека у различитим патолошким стањима. Клиничко-патолошка корелација и генетска основа тумора хипофизе и неуроендокриних тумора (RS-MESTD-Basic Research (BR or ON)-175033)
DOI: 10.1080/13685538.2017.1350155
ISSN: 1368-5538
PubMed: 28696825
WoS: 000414914800002
Scopus: 2-s2.0-85023206284
Институција/група
Fakultet organizacionih naukaTY - JOUR AU - Lončar, Goran AU - Božić, Biljana AU - Nešković, Aleksandar N. AU - Cvetinović, Nataša AU - Lainscak, Mitja AU - Prodanović, Nenad AU - Dungen, H. D. AU - von Haehling, Stephan AU - Radojičić, Zoran AU - Trippel, Tobias AU - Putniković, Biljana AU - Marković-Nikolić, Nataša AU - Popović, Vera PY - 2017 UR - https://rfos.fon.bg.ac.rs/handle/123456789/1630 AB - Purpose: We aimed at evaluating androgen status (serum testosterone [TT] and estimated free testosterone [eFT]) and its determinants in non-diabetic elderly men with heart failure (HF). Additionally, we investigated its associations with body composition and long-term survival.Methods: Seventy three non-diabetic men with HF and 20 healthy men aged over 55years were studied. Echocardiography, 6-min walk test, grip strength, body composition measurement by DEXA method were performed. TT, sex hormone binding globulin, NT-proBNP, and adipokines (adiponectin and leptin) were measured. All-cause mortality was evaluated at six years of follow-up.Results: Androgen status (TT, eFT) was similar in elderly men with HF compared to healthy controls (4.791.65 vs. 4.45 +/- 1.68ng/ml and 0.409 +/- 0.277 vs. 0.350 +/- 0.204nmol/l, respectively). In HF patients, TT was positively associated with NT-proBNP (r=0.371, p=0.001) and adiponectin levels (r=0.349, p=0.002), while inverse association was noted with fat mass (r=-0.413, p LT 0.001). TT and eFT were independently determined by age, total fat mass and adiponectin levels in elderly men with HF (p LT 0.05 for all). Androgen status was not predictor for all-cause mortality at six years of follow-up.Conclusions: In non-diabetic men with HF, androgen status is not altered and is not predictive of long-term outcome. PB - Taylor & Francis Ltd, Abingdon T2 - Aging Male T1 - Androgen status in non-diabetic elderly men with heart failure EP - 224 IS - 4 SP - 215 VL - 20 DO - 10.1080/13685538.2017.1350155 UR - conv_1978 ER -
@article{ author = "Lončar, Goran and Božić, Biljana and Nešković, Aleksandar N. and Cvetinović, Nataša and Lainscak, Mitja and Prodanović, Nenad and Dungen, H. D. and von Haehling, Stephan and Radojičić, Zoran and Trippel, Tobias and Putniković, Biljana and Marković-Nikolić, Nataša and Popović, Vera", year = "2017", abstract = "Purpose: We aimed at evaluating androgen status (serum testosterone [TT] and estimated free testosterone [eFT]) and its determinants in non-diabetic elderly men with heart failure (HF). Additionally, we investigated its associations with body composition and long-term survival.Methods: Seventy three non-diabetic men with HF and 20 healthy men aged over 55years were studied. Echocardiography, 6-min walk test, grip strength, body composition measurement by DEXA method were performed. TT, sex hormone binding globulin, NT-proBNP, and adipokines (adiponectin and leptin) were measured. All-cause mortality was evaluated at six years of follow-up.Results: Androgen status (TT, eFT) was similar in elderly men with HF compared to healthy controls (4.791.65 vs. 4.45 +/- 1.68ng/ml and 0.409 +/- 0.277 vs. 0.350 +/- 0.204nmol/l, respectively). In HF patients, TT was positively associated with NT-proBNP (r=0.371, p=0.001) and adiponectin levels (r=0.349, p=0.002), while inverse association was noted with fat mass (r=-0.413, p LT 0.001). TT and eFT were independently determined by age, total fat mass and adiponectin levels in elderly men with HF (p LT 0.05 for all). Androgen status was not predictor for all-cause mortality at six years of follow-up.Conclusions: In non-diabetic men with HF, androgen status is not altered and is not predictive of long-term outcome.", publisher = "Taylor & Francis Ltd, Abingdon", journal = "Aging Male", title = "Androgen status in non-diabetic elderly men with heart failure", pages = "224-215", number = "4", volume = "20", doi = "10.1080/13685538.2017.1350155", url = "conv_1978" }
Lončar, G., Božić, B., Nešković, A. N., Cvetinović, N., Lainscak, M., Prodanović, N., Dungen, H. D., von Haehling, S., Radojičić, Z., Trippel, T., Putniković, B., Marković-Nikolić, N.,& Popović, V.. (2017). Androgen status in non-diabetic elderly men with heart failure. in Aging Male Taylor & Francis Ltd, Abingdon., 20(4), 215-224. https://doi.org/10.1080/13685538.2017.1350155 conv_1978
Lončar G, Božić B, Nešković AN, Cvetinović N, Lainscak M, Prodanović N, Dungen HD, von Haehling S, Radojičić Z, Trippel T, Putniković B, Marković-Nikolić N, Popović V. Androgen status in non-diabetic elderly men with heart failure. in Aging Male. 2017;20(4):215-224. doi:10.1080/13685538.2017.1350155 conv_1978 .
Lončar, Goran, Božić, Biljana, Nešković, Aleksandar N., Cvetinović, Nataša, Lainscak, Mitja, Prodanović, Nenad, Dungen, H. D., von Haehling, Stephan, Radojičić, Zoran, Trippel, Tobias, Putniković, Biljana, Marković-Nikolić, Nataša, Popović, Vera, "Androgen status in non-diabetic elderly men with heart failure" in Aging Male, 20, no. 4 (2017):215-224, https://doi.org/10.1080/13685538.2017.1350155 ., conv_1978 .