Age, body mass index, and serum level of DHEA-S can predict glucocorticoid receptor function in women with polycystic ovary syndrome
Само за регистроване кориснике
2010
Аутори
Macut, Djuro![](/themes/Miragerfos/images/orcid.png)
Vojnovic Milutinović, Danijela
![](/themes/Miragerfos/images/orcid.png)
Bozić, Ivana
Matić, Gordana
![](/themes/Miragerfos/images/orcid.png)
Brkljačić, Jelena
![](/themes/Miragerfos/images/orcid.png)
Panidis, Dimitrios
Petakov, Milan
Spanos, Nikolaos
Bjekić, Jelica
Stanojlović, Olivera
![](/themes/Miragerfos/images/orcid.png)
Petrovic-Milinković, Andela
Radojičić, Zoran
![](/themes/Miragerfos/images/orcid.png)
Damjanović, Svetozar
Чланак у часопису (Објављена верзија)
![](/themes/Miragerfos//images/creativecommons/arr.png)
Метаподаци
Приказ свих података о документуАпстракт
Glucocorticoid receptor (GR) transduces the glucocorticoid (GC) signal that could lead to metabolic derangements depending on the tissue responsiveness to GC. We aimed to investigate possible causative relation of the GR functional properties in peripheral blood mononuclear cells of women with polycystic ovary syndrome (PCOS), with their clinical and biochemical characteristics. Thirty women with PCOS [mean age: 26.5 +/- A 5.1 years, mean body mass index (BMI) 24.5 +/- A 5 kg/m(2)], and thirty respective controls were analyzed for the number of GR sites per cell (B (max)), apparent equilibrium dissociation constant (K (d)), and binding potency (GR potency). A strong association between B (max) and K (d) (r = 0.70, P LT 0.0001), and GR potency with age (r = 0.49, P = 0.009) was observed in PCOS women. The multiple regression analyses within the PCOS group revealed that independent predictors for K (d) were BMI, total cholesterol, and dehydroepiandrosterone-sulfate (DHEA-S) (r = 0.58, ...P = 0.038), while for GR potency (r = 0.687, P = 0.013) were age, BMI, DHEA-S, and basal cortisol concentration. The results suggest that PCOS pathophysiology may be related to alterations of a cross stalk between glucocorticoid signaling, age, and metabolic parameters. These findings should be further explored in studies on the role of GR in PCOS-related metabolic derangements.
Кључне речи:
PCOS / Glucocorticoid-receptor-binding characteristics / Glucocorticoid receptor / DHEA-SИзвор:
Endocrine, 2010, 37, 1, 129-134Издавач:
- Springer, New York
Финансирање / пројекти:
- Експресија и функција глукокортикоидног рецептора и протеина топлотног стреса у патофизиолошким стањима и стресу (RS-MESTD-MPN2006-2010-143003)
DOI: 10.1007/s12020-009-9277-9
ISSN: 1355-008X
PubMed: 20963561
WoS: 000273851800016
Scopus: 2-s2.0-75949119842
Институција/група
Fakultet organizacionih naukaTY - JOUR AU - Macut, Djuro AU - Vojnovic Milutinović, Danijela AU - Bozić, Ivana AU - Matić, Gordana AU - Brkljačić, Jelena AU - Panidis, Dimitrios AU - Petakov, Milan AU - Spanos, Nikolaos AU - Bjekić, Jelica AU - Stanojlović, Olivera AU - Petrovic-Milinković, Andela AU - Radojičić, Zoran AU - Damjanović, Svetozar PY - 2010 UR - https://rfos.fon.bg.ac.rs/handle/123456789/593 AB - Glucocorticoid receptor (GR) transduces the glucocorticoid (GC) signal that could lead to metabolic derangements depending on the tissue responsiveness to GC. We aimed to investigate possible causative relation of the GR functional properties in peripheral blood mononuclear cells of women with polycystic ovary syndrome (PCOS), with their clinical and biochemical characteristics. Thirty women with PCOS [mean age: 26.5 +/- A 5.1 years, mean body mass index (BMI) 24.5 +/- A 5 kg/m(2)], and thirty respective controls were analyzed for the number of GR sites per cell (B (max)), apparent equilibrium dissociation constant (K (d)), and binding potency (GR potency). A strong association between B (max) and K (d) (r = 0.70, P LT 0.0001), and GR potency with age (r = 0.49, P = 0.009) was observed in PCOS women. The multiple regression analyses within the PCOS group revealed that independent predictors for K (d) were BMI, total cholesterol, and dehydroepiandrosterone-sulfate (DHEA-S) (r = 0.58, P = 0.038), while for GR potency (r = 0.687, P = 0.013) were age, BMI, DHEA-S, and basal cortisol concentration. The results suggest that PCOS pathophysiology may be related to alterations of a cross stalk between glucocorticoid signaling, age, and metabolic parameters. These findings should be further explored in studies on the role of GR in PCOS-related metabolic derangements. PB - Springer, New York T2 - Endocrine T1 - Age, body mass index, and serum level of DHEA-S can predict glucocorticoid receptor function in women with polycystic ovary syndrome EP - 134 IS - 1 SP - 129 VL - 37 DO - 10.1007/s12020-009-9277-9 UR - conv_1237 ER -
@article{ author = "Macut, Djuro and Vojnovic Milutinović, Danijela and Bozić, Ivana and Matić, Gordana and Brkljačić, Jelena and Panidis, Dimitrios and Petakov, Milan and Spanos, Nikolaos and Bjekić, Jelica and Stanojlović, Olivera and Petrovic-Milinković, Andela and Radojičić, Zoran and Damjanović, Svetozar", year = "2010", abstract = "Glucocorticoid receptor (GR) transduces the glucocorticoid (GC) signal that could lead to metabolic derangements depending on the tissue responsiveness to GC. We aimed to investigate possible causative relation of the GR functional properties in peripheral blood mononuclear cells of women with polycystic ovary syndrome (PCOS), with their clinical and biochemical characteristics. Thirty women with PCOS [mean age: 26.5 +/- A 5.1 years, mean body mass index (BMI) 24.5 +/- A 5 kg/m(2)], and thirty respective controls were analyzed for the number of GR sites per cell (B (max)), apparent equilibrium dissociation constant (K (d)), and binding potency (GR potency). A strong association between B (max) and K (d) (r = 0.70, P LT 0.0001), and GR potency with age (r = 0.49, P = 0.009) was observed in PCOS women. The multiple regression analyses within the PCOS group revealed that independent predictors for K (d) were BMI, total cholesterol, and dehydroepiandrosterone-sulfate (DHEA-S) (r = 0.58, P = 0.038), while for GR potency (r = 0.687, P = 0.013) were age, BMI, DHEA-S, and basal cortisol concentration. The results suggest that PCOS pathophysiology may be related to alterations of a cross stalk between glucocorticoid signaling, age, and metabolic parameters. These findings should be further explored in studies on the role of GR in PCOS-related metabolic derangements.", publisher = "Springer, New York", journal = "Endocrine", title = "Age, body mass index, and serum level of DHEA-S can predict glucocorticoid receptor function in women with polycystic ovary syndrome", pages = "134-129", number = "1", volume = "37", doi = "10.1007/s12020-009-9277-9", url = "conv_1237" }
Macut, D., Vojnovic Milutinović, D., Bozić, I., Matić, G., Brkljačić, J., Panidis, D., Petakov, M., Spanos, N., Bjekić, J., Stanojlović, O., Petrovic-Milinković, A., Radojičić, Z.,& Damjanović, S.. (2010). Age, body mass index, and serum level of DHEA-S can predict glucocorticoid receptor function in women with polycystic ovary syndrome. in Endocrine Springer, New York., 37(1), 129-134. https://doi.org/10.1007/s12020-009-9277-9 conv_1237
Macut D, Vojnovic Milutinović D, Bozić I, Matić G, Brkljačić J, Panidis D, Petakov M, Spanos N, Bjekić J, Stanojlović O, Petrovic-Milinković A, Radojičić Z, Damjanović S. Age, body mass index, and serum level of DHEA-S can predict glucocorticoid receptor function in women with polycystic ovary syndrome. in Endocrine. 2010;37(1):129-134. doi:10.1007/s12020-009-9277-9 conv_1237 .
Macut, Djuro, Vojnovic Milutinović, Danijela, Bozić, Ivana, Matić, Gordana, Brkljačić, Jelena, Panidis, Dimitrios, Petakov, Milan, Spanos, Nikolaos, Bjekić, Jelica, Stanojlović, Olivera, Petrovic-Milinković, Andela, Radojičić, Zoran, Damjanović, Svetozar, "Age, body mass index, and serum level of DHEA-S can predict glucocorticoid receptor function in women with polycystic ovary syndrome" in Endocrine, 37, no. 1 (2010):129-134, https://doi.org/10.1007/s12020-009-9277-9 ., conv_1237 .