Parathyroid hormone response to vitamin D insufficiency in elderly: Males with chronic heart failure
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Аутори
Božić, Biljana![](/themes/Miragerfos/images/orcid.png)
Lončar, Goran
![](/themes/Miragerfos/images/orcid.png)
Prodanović, Nenad
Lepić, Toplica
Radojičić, Zoran
![](/themes/Miragerfos/images/orcid.png)
Čvorović, Vojkan
Dimković, Siniša
Popović, Vera
Чланак у часопису (Објављена верзија)
Метаподаци
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Secondary hyperparathyroidism (SHPT) may contribute to the systemic illness that accompanies chronic heart failure (CHF). Healthy elderly with vitamin D deficiency who did not develop hyperparathyroidism (functional hypoparathyroidism, FHPT) had lower mortality than those who did. This study was designed to examine determinants of the PTH response in the vitamin D insufficient CHF patients. Sixty five vitamin D insufficient males with NYHA class II and III and 20 control subjects age ≥ 55 years were recruited. Echocardiography, physical performance, NT-pro-BNP, PTH, 25-hydroxyvitamin D (25(OH)D), adiponectin and bone activity surrogate markers (OPG, RANKL, OC, β-CTx) were assessed. Increased NYHA class was associated with SHPT, while physical performance was inferior compared to FHPT. SHPT was associated with lower left ventricular ejection fraction (LVEF) and flow mediated dilatation, but with higher left heart dimensions, left ventricular mass index and right ventricular systolic pre...ssure. CHF patients with SHPT had increased NT-pro-BNP, adiponectin and bone markers, but decreased 25(OH)D compared to those with FHPT. Independent determinants for SHPT in CHF patients with vitamin D insufficiency were LVEF, adiponectin and β-CTx, irrespective of renal function and serum vitamin D levels. In conclusion, increased PTH levels, but not low vitamin D, demonstrated close relation to CHF severity.
Кључне речи:
Vitamin D insufficiency / Response / PTH / Heart failure / Bone markers / AdiponectinИзвор:
Physiological Research, 2011, 60, SUPPL.1, S155-S163Издавач:
- Czech Academy of Sciences, Institute of Physiology
Институција/група
Fakultet organizacionih naukaTY - JOUR AU - Božić, Biljana AU - Lončar, Goran AU - Prodanović, Nenad AU - Lepić, Toplica AU - Radojičić, Zoran AU - Čvorović, Vojkan AU - Dimković, Siniša AU - Popović, Vera PY - 2011 UR - https://rfos.fon.bg.ac.rs/handle/123456789/798 AB - Secondary hyperparathyroidism (SHPT) may contribute to the systemic illness that accompanies chronic heart failure (CHF). Healthy elderly with vitamin D deficiency who did not develop hyperparathyroidism (functional hypoparathyroidism, FHPT) had lower mortality than those who did. This study was designed to examine determinants of the PTH response in the vitamin D insufficient CHF patients. Sixty five vitamin D insufficient males with NYHA class II and III and 20 control subjects age ≥ 55 years were recruited. Echocardiography, physical performance, NT-pro-BNP, PTH, 25-hydroxyvitamin D (25(OH)D), adiponectin and bone activity surrogate markers (OPG, RANKL, OC, β-CTx) were assessed. Increased NYHA class was associated with SHPT, while physical performance was inferior compared to FHPT. SHPT was associated with lower left ventricular ejection fraction (LVEF) and flow mediated dilatation, but with higher left heart dimensions, left ventricular mass index and right ventricular systolic pressure. CHF patients with SHPT had increased NT-pro-BNP, adiponectin and bone markers, but decreased 25(OH)D compared to those with FHPT. Independent determinants for SHPT in CHF patients with vitamin D insufficiency were LVEF, adiponectin and β-CTx, irrespective of renal function and serum vitamin D levels. In conclusion, increased PTH levels, but not low vitamin D, demonstrated close relation to CHF severity. PB - Czech Academy of Sciences, Institute of Physiology T2 - Physiological Research T1 - Parathyroid hormone response to vitamin D insufficiency in elderly: Males with chronic heart failure EP - S163 IS - SUPPL.1 SP - S155 VL - 60 UR - conv_3115 ER -
@article{ author = "Božić, Biljana and Lončar, Goran and Prodanović, Nenad and Lepić, Toplica and Radojičić, Zoran and Čvorović, Vojkan and Dimković, Siniša and Popović, Vera", year = "2011", abstract = "Secondary hyperparathyroidism (SHPT) may contribute to the systemic illness that accompanies chronic heart failure (CHF). Healthy elderly with vitamin D deficiency who did not develop hyperparathyroidism (functional hypoparathyroidism, FHPT) had lower mortality than those who did. This study was designed to examine determinants of the PTH response in the vitamin D insufficient CHF patients. Sixty five vitamin D insufficient males with NYHA class II and III and 20 control subjects age ≥ 55 years were recruited. Echocardiography, physical performance, NT-pro-BNP, PTH, 25-hydroxyvitamin D (25(OH)D), adiponectin and bone activity surrogate markers (OPG, RANKL, OC, β-CTx) were assessed. Increased NYHA class was associated with SHPT, while physical performance was inferior compared to FHPT. SHPT was associated with lower left ventricular ejection fraction (LVEF) and flow mediated dilatation, but with higher left heart dimensions, left ventricular mass index and right ventricular systolic pressure. CHF patients with SHPT had increased NT-pro-BNP, adiponectin and bone markers, but decreased 25(OH)D compared to those with FHPT. Independent determinants for SHPT in CHF patients with vitamin D insufficiency were LVEF, adiponectin and β-CTx, irrespective of renal function and serum vitamin D levels. In conclusion, increased PTH levels, but not low vitamin D, demonstrated close relation to CHF severity.", publisher = "Czech Academy of Sciences, Institute of Physiology", journal = "Physiological Research", title = "Parathyroid hormone response to vitamin D insufficiency in elderly: Males with chronic heart failure", pages = "S163-S155", number = "SUPPL.1", volume = "60", url = "conv_3115" }
Božić, B., Lončar, G., Prodanović, N., Lepić, T., Radojičić, Z., Čvorović, V., Dimković, S.,& Popović, V.. (2011). Parathyroid hormone response to vitamin D insufficiency in elderly: Males with chronic heart failure. in Physiological Research Czech Academy of Sciences, Institute of Physiology., 60(SUPPL.1), S155-S163. conv_3115
Božić B, Lončar G, Prodanović N, Lepić T, Radojičić Z, Čvorović V, Dimković S, Popović V. Parathyroid hormone response to vitamin D insufficiency in elderly: Males with chronic heart failure. in Physiological Research. 2011;60(SUPPL.1):S155-S163. conv_3115 .
Božić, Biljana, Lončar, Goran, Prodanović, Nenad, Lepić, Toplica, Radojičić, Zoran, Čvorović, Vojkan, Dimković, Siniša, Popović, Vera, "Parathyroid hormone response to vitamin D insufficiency in elderly: Males with chronic heart failure" in Physiological Research, 60, no. SUPPL.1 (2011):S155-S163, conv_3115 .