Relationship of reduced cerebral blood flow and heart failure severity in elderly males

Abstract

Methods. aEuro integral Seventy-one CHF males with NYHA class II and III and 20 control subjects age >= a parts per thousand yen 55 years were recruited. CBF was evaluated by colour duplex sonography of extracranial arteries. Echocardiography, 6-min walk test, quality of life and endothelial function were also assessed. Serum NT-pro-BNP and adipokines levels (adiponectin and leptin) were measured. Results. aEuro integral CBF was significantly reduced in elderly patients with CHF compared to healthy controls (677 +/-+/- 170 vs 783 +/-+/- 128 ml/min, p == 0.011). Reduced CBF was associated with reduced left ventricular ejection fraction (LVEF) (r == 0.271, p == 0.022), lower 6-min walk distance (r == 0.339, p == 0.004), deteriorated quality of life (r == --0.327, p == 0.005), increased serum adiponectin (r == --0.359, p == 0.002), and NT-pro-BNP levels (r == --0.375, p == 0.001). In multivariate regression analysis, LVEF and adiponectin were independently associated with reduced CBF in CHF patients (R LT SU2 LT /SU == 0.289). Conclusion. aEuro integral CBF was reduced in elderly males with mild-to-moderate CHF, and was associated with factors that represent the severity of CHF including high serum adiponectin and NT-pro-BNP levels, decreased LVEF, impaired physical performance, and deteriorated quality of life.